Effecacy of Alprostadil in Treating Chronic Renal Failure and Its Mechanism

Objective To observe the efficacy of alprostadil in treating the chronic renal failure(CRF) and to explore the mechanism for delaying the progression of chronic renal failure.Methods Totally 40 CRF patients were randomly divided into treatment group(n=20) and control group(n=20),The control group received conventional therapy,The treatment group,on the basis of conventional therapy,received alprostadil 10 μg intravenous infusion,q.d..Both two groups were treated for 14 days.Renal function parameters(serum creatinine,blood urea nitrogen,and creatinine clearance rate),24-hour urinary protein excretion,renal hemodynamics(inner diameter of the renal artery and interlobar arterial resistance index),hemorheology(high shear viscosity of whole blood,low shear viscosity of whole blood,plasma viscosity,erythrocyte aggregation index,erythrocyte deformation index,and hematocrit),fibrosis(hyaluronic acid,procollagen type Ⅲ,type Ⅳcollagen,and laminin) were detected before and after treatment.Results Before treatment,serum creatinine,blood urea nitrogen,creatinine clearance rate,24-hour urinary protein excretion,inner diameter of the renal artery,interlobar arterial resistance index,high shear viscosity of whole blood,low shear viscosity of whole blood,plasma viscosity,erythrocyte aggregation index,erythrocyte deformation index,hematocrit,hyaluronic acid,procollagen type Ⅲ,type Ⅳcollagen,and laminin showed no significant difference between the two groups(P0.05).After treatment,all these parameters were significantly different between these two groups(P0.05).Conclusion Alprostadil can improve renal function in CRF patients by improving renal hemodynamics and hemorheology and reducing urinary protein and renal fibrosis.