Clinical research of treatment of chronic renal failure with low-dose dopamine combined with alprostadil

Objective To observe the effect of low-dose dopamine combined with alprostadil in the treatment of chronic renal failure(CRF).Methods 100 patients with CRF were randomly divided into a treatment group(50 cases) and a control group(50 cases).The treatment group received low-dose dopamine combined with alprostadil;the control group were treated with Salvia.The two groups were given low-protein diet,and anemia and blood pressure were controled.Indexes before and after treatment such as serum creatinine(Scr),blood urea nitrogen(BUN),endogenous creatinine clearancerate(Ccr),24 h urine output,and 24h urine protein were measured and observed.Results In the treatment group,Scr and BUN decreased significantly compared with the control group while urine output increased(P0.05),but Ccr was remarkably higher than the control group.The difference was significant(P0.0 5).There was no significant difference between the two groups in terms of 24 h urinary protein.Conclusion Combination of low-dose dopamine with alprostadil is effective in the treatment of CRF.