Effects of S.yunnanensis C.H.Wright on hemodynamics in myocardial ischemia rats

Objective: To compare the effects of S.yunnanensis C.H.Wright and Slavia mitiorrhiza Bunge on hemodynamics in myocardial ischemia rats.Methods: The myocardial ischemia model was established by ligating the left anterior descending coronary artery(LAD) in rats.Both drugs were injected through femoral vein into the models.Then 1.5 h late,the whole blood viscosity,plasma viscosity,hematocrit(HCT) of red blood cell,the contents of plasma fibrinogen were observed.Results: Both drugs could markedly reduce the whole blood and plasma viscosities under high,middle and low shear rates(P0.01～0.05).With high and middle dose,the drugs could decrease the contents of plasma fibrinogen(P0.01).With high dose,both of them could reduce HCT(P0.01～0.05).Conclusion: S.yunnanensis C.H.Wright can significantly improve the hemodynamics in myocardial ischemia rats.Abstract:Objective:To compare the effects of S.yunnanensis C.H.Wright and Slavia mitiorrhiza Bunge on hemodynamics in myocardial ischemia rats.Methods:The myocardial ischemia model was established by ligating the left anterior descending coronary artery(LAD) in rats.Both drugs were injected through femoral vein into the models.Then 1.5 h late,the whole blood viscosity,plasma viscosity,hematocrit(HCT) of red blood cell,the contents of plasma fibrinogen were observed.Results:Both drugs could markedly reduce the whole blood and plasma viscosities under high,middle and low shear rates(P0.01~0.05).With high and middle dose,the drugs could decrease the contents of plasma fibrinogen(P0.01).With high dose,both of them could reduce HCT(P0.01~0.05).Conclusion:S.yunnanensis C.H.Wright can significantly improve the hemodynamics in myocardial ischemia rats.