Efficacy and safety of benazepril alone or in combination with lercanidipine

Objective To observe the efficacy and safety of benazepril alone or in combination with lercanidipine in patients with mild to moderate essential hypertension.Methods Among 138 patients with mild to moderate essential hypertention treated with benazepril 10 mg/d for 4 weeks,89 patients with seated diastolic blood pressure(SeDBP) remained≥90 mmHg were randomly divided to group A(benazepril 10 mg,lercanidipine 10 mg) and group B(benazepril 20 mg).At the end of 4 weeks,patients with SeDBP≥90mmHg were doubled the dosage of the initial regimen for additional 4 weeks,and the patients with SeDBP90 mmHg remained the initial regimen to 4 weeks.Results The blood pressure in group A was lower than that in group B at the end of 8 weeks(P0.05).Compared with group B,the reaching target blood pressure rate in group A was better at the end of 4 and 8 weeks(76.2%vs 60.1%,P0.05;88.1%vs 67.4%,P 0.05).There was no significant difference in adverse reaction between both groups.Conclusion Benazepril combined with lercanidipine for mild to moderate essential hypertension patients is effective in improving blood pressure,and the patients are well tolerated.