The changes and clinical significance of the platelet parameters in patients with ischemic stroke

Objective To study the changes and clinical significance of platelet count,mean platelet volume and maximum platelet aggregation rate in patients with ischemic stroke.Methods One hundred and sixty-eight cases of ischemic stroke(both acute and convalescence) and 40 normal controls were tested for their levels of platelet count,mean platelet volume,maximum platelet aggregation rate and their correlations with neurological functional deficit scale.Results The levels of mean platelet volume and maximum platelet aggregation rate in acute phase in ischemic stroke were markedly higher than those in convalescence((P)0.01)and in controls((P)0.01).The levels of mean platelet volume and maximum platelet aggregation rate in convalescence were still higher than those of the controls((P)0.01).The acute phase of ischemic stroke were divided into four subtypes according to the oxfordshire community stroke project(OCSP),the levels of mean platelet volume and maximum platelet aggregation rate in ischemic stroke were obviously higher in total anterior circulation infarcts(TACI) group than those of partial anterior circulation infarcts(PACI),posterior circulation infacts(POCI) and lacunar infacts(LACI) group((P)0.01),while PACI and POCI group were markedly higher than LACI group((P)0.01),but there is no signifcant difference between PACI and POCI group((P)0.05).The levels of mean platelet volume and maximum platelet aggregation rate were positively related with neurological functional deficit scale(r=0.684 or 0.698,(P)0.01).No signifcant difference in the platelet count was found in all the groups,the platelet count was not correlated to the neurological functional deficit scale(r=0.32,(P)0.05).Conclusion Mean platelet volume and maximum platelet aggregation rate are much sensitive to reflect seriousness and predict prognosis of disease,they are good platelet parameter indexes.