Feasibility study of the changes of serum lectin in guiding early diagnosis of liver cancer

Objective To study the feasibility and clinical value of serum protein markers for early diagnosis of liver cancer. Methods A total of 60 patients with hepatocellular carcinoma( A group),35 patients with liver cirrhosis( B group), 15 patients with other diseases( C group),15 healthy persons( control group) were selected for the study. Venous blood was collected to detect alpha- fetoprotein( AFP),AFP heterogeneity( AFP- L3),Golgi membrance protein 73( CP73),the correlation of tumor size and BCLC classification was analyzed.Results The serum AFP,AFP- L3,GP73 levels in group A were significantly higher than those in other three groups( P 0. 05). There was no significant correlation between tumor size and serum levels of AFP and GP73,and there was significant correlation between tumor size and serum AFP- L3; no significant correlation between the number of tumors and serum AFP,AFP- L3,CP73. There was a positive correlation between BCLC classification and AFP,AFP- L3,the sensitivity of AFP was85. 7%, specificity was 72. 9%; the sensitivity of AFP- L3 was58. 0%,specificity was 87. 6%; the sensitivity of GP73 was 69. 7%,specificity was 76. 7%. Parallel test joint detection method can improve the sensitivity and negative predictive value of detection; series of tests combined detection method can improve the specificity and positivepredictive value. Conclusion Serum AFP,AFP- L3,CP73 joint detection and using positive complementary can significantly improve the accuracy of hepatic tumors diagnosis.