Experimental Study on How Salvia Miltiorrhiza Works on Changes of Free Radical at Early Stage of Spinal Cord Injury

Objective To investigate the changes of free radical in blood and spinal cord at early stage of spinal cord injury(SCI)in animal model and the changes after using Salvia Miltiorrhiza.Methods32rabbits were divided into four groups:control group,injury group,demasorb(DMSO)group and Salvia Miltiorrhiza group.Each group contained8rabbits.All spinal cord injury models were made in Allen's way.Except control group and injury group,rabbits in DMSO and Salvia Miltiorrhiza groups were seperately injected DMSO and Salvia Miltiorrhiza into cavitas abdominis after30mins,2hours and4hours of SCI.The level of malondialdehyde(MDA)and superoxide dismutase(SOD)were tested in all samples and histological examination under optical microscope were made at the same time.Results MDA increased and SOD decreased in injuriy group while MDA decreased but SOD increased in the Salvia Miltiorrhiza group.The white tissue of spinal cord decreased in injury group which remained healthy in Salvia Miltiorrhiza group.The data of two groups had significant differences.Conclusions Free radicals inˉcreased after SCI but could be eliminated efficiently by injecting Salvia Miltiorrhiza.Salvia Miltioriza can greatly prevent the further injury of spinal cord after SCI.After injecting Salvia Miltiorrhiza,MDA decreased.SOD inˉcreased.