2006•Tianjin yiyaoRequires access
The Effection of QiZhuHeJi Treating Rats with Pulmonary Fibrosis on TGF-β_1
Meilin Xu
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Abstract
Objective: To discuss the curative function of QiZhuHeJi on rats with pulmonary fibrosis. Methods: Sixty rats were randomly divided into group A of the normal control? group B of the model?group C of the QiZhuHeJi and group D of the prednisone. The rat pulmonary fibrosis models were made by injecting blemycin through tracheal and cured respectively,rats in each group were made to die (six rats every time in each group)three,seven and twenty-one days after curation.The expression of transforming growth factor-β1( TGF-β1) was measured by using immunohistochemistry and the content of hyaluronis acid(HA) and the level of bronchoalveolar lavage inflammatory cells were detected too. Results: The increase of TGF-β1 expression was obvious with time,the difference was statistically significant compared with the normal group(P0.01). The TGF-β1 expression in the QiZhuHeJi group was lower than that of the model group. Conclusion: Blemycin make pulmonary fibrosis rats to obtain a high expression condition of TGF-β1 in different time and QiZhuHeJi can depress pulmonary fibrosis by repressing TGF-β1 expression and decreasing the level of HA.