Therapeutic effect of atorvastatin with difference doses on early acute coronary syndrome in aged patients

Objective: To observe clinical therapeutic effect and safety of atorvastatin with different doses on early acute coronary syndrome(ACS) in aged patients.Methods: A total of 117 ACS aged patients were randomly divided into atorvastatin 10mg group(n=58) and 20mg group(n=59).Levels of total cholesterol(TC),low density lipoprotein-cholesterol(LDL-C),high density lipoprotein-cholesterol(HDL-C),triglyceride(TG) and high sensitive C-reactive protein(hsCRP) were measured before,one and three months after treatment.All adverse reactions and incidence rates of major adverse cardiovascular events(MACE)were followed up during three months after treatment.Results:(1) Compared with before treatment,levels of TC,LDL-C and hsCRP significantly decreased in the two groups on first and third month after treatment(P0.05 all).After third month,compared with 10 mg group decrease levels of TC[(4.07±1.03) mmol/L vs.(5.02±1.08) mmol/L],LDL-C[(2.24±0.77) mmol/L vs.(3.03±1.07) mmol/L] and hsCRP[(27.90±1.90)mg/L vs.(36.00±3.80) mg/L] more than those in 20 mg group(P0.05 all);(2) Overall incidence rates of MACE in 20 mg group was significantly lower than that of 10 mg group(5.1% vs.19.0%,P0.05);(3) There was no significant difference in incidence rate of adverse reactions between the two groups and no severe adverse reactions occurred.Conclusion: Application of atorvastatin 20 mg/d in early ACS can effectively lower blood lipids,and inflammatory factors,decrease MACE rate,and is safe.