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Protective effect of ginsenosides on acute cerebral ischemia/reperfusion injury of rats

Xiu Chen

Open publisher page 6 citations

Abstract

Acute cerebral i schemia/reper-fusion injury of rat was produced by 4-vessel occlusion.Ginsenosides 100 mg/kg iv 30 min before ischemia significantly improved brain electrical activity and SOD ac-tivity reduced brain edema and suppressed the rise of lipid peroxides and LDH release in brain after 40 min ischemia/reperfusion.These improvements indicate that ginseno-sides have protective effect on cerebral ischemia/reperfusion injury probably by inhibiting free radicals and subsequent lipid peroxidation.

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What this paper is about

Acute cerebral i schemia/reper-fusion injury of rat was produced by 4-vessel occlusion.Ginsenosides 100 mg/kg iv 30 min before ischemia significantly improved brain electrical activity and SOD ac-tivity reduced brain edema and suppressed the rise of lipid peroxides and LDH release in brain after 40 min ischemia/reperfusion.These improvements indicate that ginseno-sides have protective effect on cerebral ischemia/reperfusion injury probably by inhibiting free radicals and subsequent lipid peroxidation.

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Available abstract

Acute cerebral i schemia/reper-fusion injury of rat was produced by 4-vessel occlusion.Ginsenosides 100 mg/kg iv 30 min before ischemia significantly improved brain electrical activity and SOD ac-tivity reduced brain edema and suppressed the rise of lipid peroxides and LDH release in brain after 40 min ischemia/reperfusion.These improvements indicate that ginseno-sides have protective effect on cerebral ischemia/reperfusion injury probably by inhibiting free radicals and subsequent lipid peroxidation.

Key concepts: Ischemia, Lipid peroxidation, Pharmacology, Reperfusion injury, Anesthesia, Medicine, Cerebral edema, Brain edema

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Protective effect of ginsenosides on acute cerebral ischemia/reperfusion injury of rats — Research Paper | ScholarLens