Clinical Significance of Serum Cystatin C Determination in the Early Diagnosis of Diabetic and Hypertensive Nephropathy

Objective To investigate the clinical significance of serum cystatin C(Cys-C) determination in early screening and monitoring primary chronic kidney diseases(CKD) induced by hypertension and diabetes.Methods We collected the serum of 89 patients with diabetes-induced and 76 patients with hypertension induced CKDs treated between July 2007 and March 2009.The concentrations of Cys-C,blood urea nitrogen(BUN),serum creatinine(Scr),and urinary albumin excretion rate(UAER) in the patients were detected by particle enhanced turbidimetric immunoassay.Then,based on UAER,we analyzed the relationship between Cys-C and traditional parameters in renal function injury.Results The concentrations of serum Cys-C and UAER in early nephropathy patients were significantly different from the normal controls(P0.01),while there was no statistical difference in traditional parameters like BUN and Scr(P0.05).For patients with intermediate or advanced renal injury,the concentration of serum Cys-C was significantly correlated with UAER,BUN and Scr(r=0.936,0.692,0.653,P0.01).Conclusion Compared with BUN and Scr,serum Cys-C is a more accurate and sensitive parameter in reflecting early nephropathy,and it is of important clinical value in monitoring the complications of the diabetic or hypertensive nephropathy.