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THE CHANGES OF GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP)-IMMUNOREACTIVITY IN THE SEIZURE SENSITIVE RAT BRAIN

Sun Shin Yi

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Abstract

Seizure episodes were induced by administration of kainic acid (10mg/ kg s.c.) in the Sprague-Dawley rats. One month later, the changes of glial fibrillary acidic protein (G F A P)- immunoreactive elements in the rat brain were examined by using immunocytochemical method. Intensive GFAP-im munostainings were found in CA1, CA2, subiculum and ventral hilus of hippocampal formation as well as related areas including amygdaloid, piriform, entorhinal cortex, septum area, accumbens and caudal part of caudate putamen.This phenomenon may associated with neuronal damage during and after seizure episodes.

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What this paper is about

Seizure episodes were induced by administration of kainic acid (10mg/ kg s.c.) in the Sprague-Dawley rats. One month later, the changes of glial fibrillary acidic protein (G F A P)- immunoreactive elements in the rat brain were examined by using immunocytochemical method. Intensive GFAP-im munostainings were found in CA1, CA2, subiculum and ventral hilus of hippocampal formation as well as related areas including amygdaloid, piriform, entorhinal cortex, septum area, accumbens and caudal part of caudate putamen.This phenomenon may associated with neuronal damage during and after seizure episodes.

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Available abstract

Seizure episodes were induced by administration of kainic acid (10mg/ kg s.c.) in the Sprague-Dawley rats. One month later, the changes of glial fibrillary acidic protein (G F A P)- immunoreactive elements in the rat brain were examined by using immunocytochemical method. Intensive GFAP-im munostainings were found in CA1, CA2, subiculum and ventral hilus of hippocampal formation as well as related areas including amygdaloid, piriform, entorhinal cortex, septum area, accumbens and caudal part of caudate putamen.This phenomenon may associated with neuronal damage during and after seizure episodes.

Key concepts: Glial fibrillary acidic protein, Piriform cortex, Subiculum, Kainic acid, Hippocampal formation, Entorhinal cortex, Hippocampus, GFAP stain

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THE CHANGES OF GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP)-IMMUNOREACTIVITY IN THE SEIZURE SENSITIVE RAT BRAIN — Research Paper | ScholarLens