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2004•Chinese Journal of Clinical NeurosciencesRequires access

The Change of Neurons and Glial Fibrillary Acidic Protein(GFAP) Immunoreactivityin Entorhinal Cortex of Seizure Sensitive Rats

Cheng Wei

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Abstract

Aim:To explore the change of neurons and glial fibrillary acidic protein(GFAP) immunoreactivity in entorhinal cortex (EC)of seizure sensitive rats.Methods:Seizure episodes were induced by administration of kainic acid (10 mg·kg -1 )in the Sprague-Dawley rats.One month later,the change of neurons and GFAP immunoreactivity in entorhinal cortex of rats was examined by using immunocytochemical method and thionin staining.Results:As compared with control group,the fewer neurons and the more intensive GFAP immunostainings were found in the entorhinal cortex.Conclusion:The phenomenon may be associated with the long-term enhancement of seizure susceptibility.

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What this paper is about

Aim:To explore the change of neurons and glial fibrillary acidic protein(GFAP) immunoreactivity in entorhinal cortex (EC)of seizure sensitive rats.Methods:Seizure episodes were induced by administration of kainic acid (10 mg·kg -1 )in the Sprague-Dawley rats.One month later,the change of neurons and GFAP immunoreactivity in entorhinal cortex of rats was examined by using immunocytochemical method and thionin staining.Results:As compared with control group,the fewer neurons and the more intensive GFAP immunostainings were found in the entorhinal cortex.Conclusion:The phenomenon may be associated with the long-term enhancement of seizure susceptibility.

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Available abstract

Aim:To explore the change of neurons and glial fibrillary acidic protein(GFAP) immunoreactivity in entorhinal cortex (EC)of seizure sensitive rats.Methods:Seizure episodes were induced by administration of kainic acid (10 mg·kg -1 )in the Sprague-Dawley rats.One month later,the change of neurons and GFAP immunoreactivity in entorhinal cortex of rats was examined by using immunocytochemical method and thionin staining.Results:As compared with control group,the fewer neurons and the more intensive GFAP immunostainings were found in the entorhinal cortex.Conclusion:The phenomenon may be associated with the long-term enhancement of seizure susceptibility.

Key concepts: Glial fibrillary acidic protein, Entorhinal cortex, Kainic acid, Neuroscience, Astrocyte, Hippocampus, Cortex (anatomy), GFAP stain

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