1998•Neuroscience Research CommunicationsRequires access
Glial reaction linked with P70-induced seizure activity in the cerebral cortex of rats
Minoru Onozuka, Kazuko Watanabe, Haruko Takada, Seyed Mohammad MIRBOD, Nobuyuki Karasawa, Ikuko Nagatsu, Katsuhiro Nishiyama, Satoru Ozono
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Abstract
An anti-glial fibrillary acidic protein (GFAP) antibody was used to study the glial reaction linked to P70-induced seizure activity in the rat cerebral cortex. GFAP-immunoreactivity was restricted to astrocytes within the epileptogenic cortex showing epileptogenic discharges on the electrocorticogram (ECoG) on intracortical application of P70, and the number of GFAP-positive cells increased with the duration of seizure activity. However, the induction of these astrocytes was suppressed by the anticonvulsants, phenytoin (PHT) or phenobarbital (PB). The data suggest that P70-induced seizure activity elicits the generation of fibrous astrocytes in the cerebral cortex.