The expressions and their significances of CD147,matrix metalloproteinase-9 and vascular endothelial growth factor in renal cell carcinoma

Objective:To study the expressions of CD147,Matrix metalloproteinase-9(MMP-9) and vascular endothelial growth factor(VEGF) in renal cell carcinoma(RCC),and explore their correlations with tumor growth,tumor invasion and metastasis.Methods:The expressions of CD147,MMP-9 and VEGF were detected by immunohistochemical SP method in tissue from the carcinoma(RCC,n=107) and normal renal tissue(n=10).The relationships between the expressions and clinical pathology were analyzed,and the correlations among CD147,MMP-9 and VEGF were studied.Results:The expressions of CD147,MMP-9 and VEGF in RCC were significantly higher than those in normal renal tissue(P0.01),which had no statistical significance related to pathological type(P0.05),but had statistical significances related to clinical staging(P0.01).A positive correlation among CD147,MMP-9 and VEGF was observed(P0.01).Furthermore,the expression of CD147 was statistical significance associated with tumor size,clinical stage and distant metastasis(P0.01),but not with age and gender(P0.05).Conclusions:CD147,MMP-9 and VEGF play the important role in the progression and invasion in RCC,the detection of CD147,MMP-9 and VEGF expressions may be the potential biological indexes which reflect tumor growth,invasion and metastasis of RCC.