EXPRESSION OF MMP-9 AND VEGF IN THE TISSUES OF RENAL CARCINOMA AND ITS CORRELATION WITH MVD

Objective To study the expressions of MMP-9 and VEGF in renal carcinoma, and their correlation with angiogenesis, tumor invasion and metastasis. Methods Expressions of MMP-9 and VEGF were detected immunohistochemically in tissue from the carcinoma (RCC, n=75) and normal renal tissue (n=12). The MVD was estimated via counting the number of endothelium displayed by CD34 expression. Results Expressions of MMP-9 and VEGF in RCC were significantly higher than that of normal renal tissue (F=13.12;9.76;q=4.568-9.333;P0.05), which were not related to pathological type (P0.05), but related to clinical staging (F=24.95,3.54;q=3.086-11.846,P0.05). A positive correlation between MVD, MMP-9 and VEGF was observed (r=0.381,0.375;P0.05). Conclusion MMP-9 and VEGF correlate significantly with angiogenesis in RCC, suggesting of expressions of MMP-9 and VEGF may be biological indexes in detecting invasion and metastasis of RCC.