ScholarLens Back to search
2007•Chongqing yixueRequires access

Expression and clinical significance of MMP-9,VEGF in renal cell carcinoma

Sun Xiangyu

Open publisher page 0 citations

Abstract

Objective To study the expressions of matrix metalloproteinase-9(MMP-9),vascular endothelial growth factor(VEGF) and their correlation with angiogenesis and biological behaviour in renal cell carcinoma(RCC).Methods The expressions of MMP-9,VEGF and CD34 were detected by means of immunohistochemistry in 78 cases of RCC.Results The positive expression rate of MMP-9 was 87% in the high staging group and 50% in the low staging group,the statistical significance existed between the two groups(P0.01);the MVD was 140.86±24.87 in both positive expressions of MMP-9 and VEGF,was higher than that in the single positive ones(99.3±47.97)(P0.01)and the both negative ones(80.16±33.83)(P0.000 1).The expression of MMP-9 correlated with VEGF in renal cell carcinoma(r=0.409 66,P0.01).Conclusion MMP-9 and VEGF may serve as biological predictor for tumor metastatic potential in renal cell carcinoma.

About this research paper

What this paper is about

Objective To study the expressions of matrix metalloproteinase-9(MMP-9),vascular endothelial growth factor(VEGF) and their correlation with angiogenesis and biological behaviour in renal cell carcinoma(RCC).Methods The expressions of MMP-9,VEGF and CD34 were detected by means of immunohistochemistry in 78 cases of RCC.Results The positive expression rate of MMP-9 was 87% in the high staging group and 50% in the low staging group,the statistical significance existed between the two groups(P0.01);the MVD was 140.86±24.87 in both positive expressions of MMP-9 and VEGF,was higher than that in the single positive ones(99.3±47.97)(P0.01)and the both negative ones(80.16±33.83)(P0.000 1).The expression of MMP-9 correlated with VEGF in renal cell carcinoma(r=0.409 66,P0.01).Conclusion MMP-9 and VEGF may serve as biological predictor for tumor metastatic potential in renal cell carcinoma.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To study the expressions of matrix metalloproteinase-9(MMP-9),vascular endothelial growth factor(VEGF) and their correlation with angiogenesis and biological behaviour in renal cell carcinoma(RCC).Methods The expressions of MMP-9,VEGF and CD34 were detected by means of immunohistochemistry in 78 cases of RCC.Results The positive expression rate of MMP-9 was 87% in the high staging group and 50% in the low staging group,the statistical significance existed between the two groups(P0.01);the MVD was 140.86±24.87 in both positive expressions of MMP-9 and VEGF,was higher than that in the single positive ones(99.3±47.97)(P0.01)and the both negative ones(80.16±33.83)(P0.000 1).The expression of MMP-9 correlated with VEGF in renal cell carcinoma(r=0.409 66,P0.01).Conclusion MMP-9 and VEGF may serve as biological predictor for tumor metastatic potential in renal cell carcinoma.

Key concepts: Renal cell carcinoma, Matrix metalloproteinase, CD34, Angiogenesis, Vascular endothelial growth factor, Immunohistochemistry, Medicine, VEGF receptors

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Expression and clinical significance of MMP-9,VEGF in renal cell carcinoma — Research Paper | ScholarLens