Leptin and gestiaonal diabetes mellitus

Gestational diabetes mellitus(GDM),which brings the patient some serious clinical complications,is defined as any degree of glucose intolerance with onset or first recognition during pregnancy.The prevalence is increasing year by year.The development of GDM is related to insulin resistance.Leptin,produced by adipose cells,regulates fat and energy metabolisms through central and peripheral approaches and is closely related to obesity and insulin resistance.Insulin can stimulate production and secretion of leptin in the adpose tissues.On the other hand,leptin can inhibit insulin.GDM patients coexist hyperleptinemia,hyperinsulinemia,hyperglycemia in their body,and develop insulin resistance and leptin resistance.The imbalance of adipo-insulin endocrine axis is associated with occurrence and development of GDM.