CORRELATION STUDY BETWEEN LN、MMP-9 EXPRESSIONS AND LARYNGEAL CARCINOMA

Objective To investigate the expressions of laminin(LN) and matrix metalloproteinase-9(MMP-9) in laryngeal carcinoma and its relationship with the biological behavior in laryngeal carcinoma and to research the mechanism of carcinogenesis;we also analyze the correlation between LN and MMP-9.Methods The technology of immunohistochemistry SP was used to detect the expressions of LN and MMP-9 in the 46 cases of laryngeal carcinoma and those in 30 cases normal mucosa respectively.In addition,several clinic pathological features were analyzed.Results The positive expression rates of LN and MMP-9 in laryngeal carcinoma were 73.9%and 70% respectively,higher than those of being 23.3% and 16.7% in normal laryngeal tissues.In laryngeal carcinoma,the intensive expression rates of LN and MMP-9 had a positive relationship with the situation of cervical lymph node matastasis.Significant correlation was found between the expression of LN and that of MMP-9 in laryngeal carcinoma.Conclusion LN and MMP-9 show positive expressions in laryngeal carcinoma.The degree of expressions of LN and MMP-9 have relevance to the degree of differentiation,clinical stage and cervical lymph node matastasis of laryngeal carcinoma.The expressions of LN and MMP-9 in laryngeal carcinoma were positively correlated,playing synergistic effect during the process of occurrence and metastasis of laryngeal carcinoma.