2013•Kunming Yike Daxue xuebaoRequires access
Expression of ET-1 and MMP-2 in Laryngeal Carcinoma and Their Meanings
Lin Yan
Open publisher page 0 citations
Abstract
Objective To investigate the expressions of endothelin-l(ET-1) and matrix metallproteinase-2(MMP-2)in laryngeal carcinoma,and study the correlation of expression and laryngeal carcinoma relevant characteristics.Methods The expressions of ET-1 and MMP-2 in 52 samples of laryngeal carcinoma were detected and analyzed by using the immunohistochemical SP method.And 28 samples of vocal polyp and 19 samples of normal laryngeal mucosa tissue were selected as control.Results The intense expression(71.15%)of ET-1 of laryngeal carcinoma patients was significantly higher than that of the control group(P 0.05).And the intense expression(69.23%) of MMP-2 in laryngeal carcinoma patients was significantly higher than that of the control group(P 0.05).There was a positive correlation between the ET-1 and MMP-2 expressions of laryngeal carcinoma.Conclusion The high expressions of ET-1 and MMP-2 were related to the invasion and aggressiveness in laryngeal carcinoma and could be used as effective markers for diagnosis.ET-1 and MMP-2 may be synergies for promoting the formation and development of laryngeal carcinoma.