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Studies on the Characteristics of Freeze-Dried Solid Lipid Nanoparticles Loading Mifepristone

Hou Dong

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Abstract

AIM:Several cryoprotectants were employed to study the protective effect on the drug loading solid lipid nanoparticles(SLN) in order to select the optimum formulation.METHOD:The protective effect was evaluated by encapsulation efficiency and mean particle size of samples before and after freeze-drying process,and the morphologic study was performed by TEM and AFM.RESULT:The excellent protective effect could be obtained when trehalose was added to the sample with the concentration of 20%.Excellent sample was with the EE% of 79%(versus 88% of fresh one),mean particle size of 247 nm(versus 109 nm of fresh one),and a much lowered polydispersity index of 0.121(versus 0.246).CONCLUSION:The satisfactory result could be achieved with suitable type of cryoprotectant with appropriate concentration and proper freeze-drying condition.

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AIM:Several cryoprotectants were employed to study the protective effect on the drug loading solid lipid nanoparticles(SLN) in order to select the optimum formulation.METHOD:The protective effect was evaluated by encapsulation efficiency and mean particle size of samples before and after freeze-drying process,and the morphologic study was performed by TEM and AFM.RESULT:The excellent protective effect could be obtained when trehalose was added to the sample with the concentration of 20%.Excellent sample was with the EE% of 79%(versus 88% of fresh one),mean particle size of 247 nm(versus 109 nm of fresh one),and a much lowered polydispersity index of 0.121(versus 0.246).CONCLUSION:The satisfactory result could be achieved with suitable type of cryoprotectant with appropriate concentration and proper freeze-drying condition.

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Available abstract

AIM:Several cryoprotectants were employed to study the protective effect on the drug loading solid lipid nanoparticles(SLN) in order to select the optimum formulation.METHOD:The protective effect was evaluated by encapsulation efficiency and mean particle size of samples before and after freeze-drying process,and the morphologic study was performed by TEM and AFM.RESULT:The excellent protective effect could be obtained when trehalose was added to the sample with the concentration of 20%.Excellent sample was with the EE% of 79%(versus 88% of fresh one),mean particle size of 247 nm(versus 109 nm of fresh one),and a much lowered polydispersity index of 0.121(versus 0.246).CONCLUSION:The satisfactory result could be achieved with suitable type of cryoprotectant with appropriate concentration and proper freeze-drying condition.

Key concepts: Cryoprotectant, Dispersity, Trehalose, Solid lipid nanoparticle, Freeze-drying, Particle size, Chromatography, Chemistry

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