2007•PubMedRequires access

[Freeze-drying of oleanolic acid-loaded nanosuspensions].

Xiaoling Zhao, Hua-Bing Chen, Yajun Chen, Xiangliang Yang

Abstract

OBJECTIVE: Several cryoprotectants were employed to study the protective effect on the freeze-drying process of the oleanolic acid-loaded nanosuspensions (OLA-LS) in order to select the optimum formulation. METHOD: The protective effect was evaluated by measuring the mean particle size of samples before and after freeze-drying process. RESULT: Sucrose with the concentration of 10% was selected as the optimum cryoprotectant. The average size of excellent sample was 236.3 nm (versus 211.2 nm of fresh one), and a much higher polydispersity index of 0.242 (versus 0.180). CONCLUSION: The optimum lyophilized powder could be obtained with suitable type of cryoprotectant with appropriate concentration and proper freeze-drying conditions.

About this research paper

What this paper is about

Why it matters

OpenAlex reports 4 citations for this work. Citation counts describe recorded attention and do not establish research quality.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Cryoprotectant, Freeze-drying, Dispersity, Chromatography, Particle size, Oleanolic acid, Chemistry, Materials science