Effect of lamirudine in treatment of hepatitis B and liver cirrhosis ascites

Objective To observe the clinical effect of lamivudine in the treatment of hepatitis B and liver cirrhosis ascites.Methods Eighty-two patients with hepatitis B and liver cirrhosis diagnosed during Jan.2006 to Jan.2007 were divided into treatment group(39 cases)and control group(43 cases).The control group received the routine colligation therapy and the treatment group received lamivudine on the base of routine colligation therapy.Change of hepatic function(ALT,TB,ALB,PTA)and liver fibrosis marker amelioration and ascites extinction effect were observed.Results Compared with control group,the hepatic function of treatment group was improved(P0.05)and ascites was improved too(χ2=9.17,P0.01).Conclusion Lamivudine can improve hepatic function,reduce liver fibrosis marker and accelerate ascites extinction.