ScholarLens Back to search
1988•Unpublished venueRequires access

STUDIES ON ANTITHROMBOTIC EFFECT OF POLYUNSATURATED ACIDS FROM FISH OIL

Jian Wang

Open publisher page 0 citations

Abstract

Polyunsaturated fatty acids(PUFA),containing docosahexaenoicacid(DHA)33% and eicosapentaenoic acid(EPA)10%,prepared from Navodonseptentrionalis(Gunther)liver oil with solvent crystallization,were used for an-tithrombotic studies.After fed with PUFA 5 or 10ml/kg for 7 days,thrombusweight and ADP-induced platelets aggregation reduced in rats,bleeding timewere prolonged in mice.In healthy volunteers,PUFA led the reduction of ADPor adrenaline-induced platelets aggregation and platelet adherence,and prolongof bleeding time.Three grams daily of PUFA was recommended as clinical dose.

About this research paper

What this paper is about

Polyunsaturated fatty acids(PUFA),containing docosahexaenoicacid(DHA)33% and eicosapentaenoic acid(EPA)10%,prepared from Navodonseptentrionalis(Gunther)liver oil with solvent crystallization,were used for an-tithrombotic studies.After fed with PUFA 5 or 10ml/kg for 7 days,thrombusweight and ADP-induced platelets aggregation reduced in rats,bleeding timewere prolonged in mice.In healthy volunteers,PUFA led the reduction of ADPor adrenaline-induced platelets aggregation and platelet adherence,and prolongof bleeding time.Three grams daily of PUFA was recommended as clinical dose.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Polyunsaturated fatty acids(PUFA),containing docosahexaenoicacid(DHA)33% and eicosapentaenoic acid(EPA)10%,prepared from Navodonseptentrionalis(Gunther)liver oil with solvent crystallization,were used for an-tithrombotic studies.After fed with PUFA 5 or 10ml/kg for 7 days,thrombusweight and ADP-induced platelets aggregation reduced in rats,bleeding timewere prolonged in mice.In healthy volunteers,PUFA led the reduction of ADPor adrenaline-induced platelets aggregation and platelet adherence,and prolongof bleeding time.Three grams daily of PUFA was recommended as clinical dose.

Key concepts: Polyunsaturated fatty acid, Eicosapentaenoic acid, Antithrombotic, Fish oil, Platelet, Cod liver oil, Platelet aggregation, Chemistry

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
STUDIES ON ANTITHROMBOTIC EFFECT OF POLYUNSATURATED ACIDS FROM FISH OIL — Research Paper | ScholarLens