Experimental studies on anti-inflammatory and analgesic action of the Tongmaiyushang capsule

Objective To study the anti-inflammatory and analgesic effects of Tongmaiyushang capsule.Methods Tumidness of small rat ears was induced by dimethylbenzene.Acute and chronic inflammation of rats were induced by carrageenin and tampon embedding respectively.The pain model was made by hot plate and writhing tests.Animals were divided into five groups: the blank control group;the positive control group;the low,middle and high dose of Tongmaiyushang capsule groups to investigate the anti-inflammatory and analgesic effect of the Tongmaiyushang capsule.Results The capillary permeability was decreased and the effusion of inflammatory mediator was reduced in small rat.Tumidness of small rat ears caused by dimethylbenzene and inflammation reaction induced by carrageenin were significantly inhibited with the reduction of leukocytes.The hyperplasia of granulation tissue in rats was also be inhibited.The capsule could improve the threshold of pain,prolong the incubation period of pain,decrease the quantity of body wrest of small rats.The analgesia rate of three groups was 49.6%,43.5%,33.3%,respectively.Conclusion Tongmaiyushang capsule has good anti-inflammatory and analgesic effects.