Correlations Among Plasma Level of Homocysteine,High-Sensitivity C-Reactive Protein and Cerebral Large-Artery Atherosclerosis

Objective To investigate the relationship among plasma homocysteine(Hcy)and high-sensitivity C-reactive protein(hsCRP)and cerebral large-artery atherosclerotic stenosis.Methods 94 adult patients with ischemic cerebrovascular disease experienced digital subtraction angiography(DSA)were enrolled,and 68 patients with potential large-artery atherosclerotic stenosis(grade50%,at least one vessel)and 26 patients without stenosis or mild grade(grade≤50%)were included as control.Plasma Hcy and hsCRP level were analyzed and conventional risk factors of cerebral stroke such as sex,age,hypertension,diabetes,long-smoking,and plasma levels of triglyceride,high-density lipoprotein,low-density lipoprotein were evaluated in all subjects.Results Both plasma concentration of Hcy and hsCRP and the proportion of subjects with high level of Hcy and hsCRP were significantly higher in patients with potential atherosclerotic stenosis than control.Based on multivariable stepwise logistic regression model,Hcy,hsCRP,hypertension,diabetes,long-smoking were closely related to large-artery atherosclerotic stenosis.The severer the large-artery atherosclerotic stenosis is,the higher Hcy and hsCRP concentration in the blood.Conclusion High level of plasma homocysteine and high-sensitivity C-reactive protein are closely related to cerebral large-artery atherosclerosis.High concentrations of Hcy and hsCRP are risk factors of cerebral large-artery atherosclerotic stenosis.