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2008•Chinese Journal of Public HealthRequires access

Research on genotoxicity of bactericide flutriafol

Hui Xiu-juan

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Abstract

Objective To study the genotoxicity of bactericide flutriafol.Methods The Ames test,micronucleus test and comet assay were used to detect the genotoxicity of bactericide flutriafol.Results With and without S9 activation,there were negative results of the TA97,TA98,TA100 and TA102 strains in Ames test.The micronucleus rates in all doses were not significantly different from that of the control group.For the tail DNA% of comet assay there was a significant difference between the negative control and the treated group(P0.05) in dose of 80 mg/(kg·bw),while there was no significant difference between the negative control and the treated groups(P0.05) in other dose.The results of genetic toxicity tests were all negative.Conclusion The bactericide flutriafol had no genetic toxicity in this test.

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What this paper is about

Objective To study the genotoxicity of bactericide flutriafol.Methods The Ames test,micronucleus test and comet assay were used to detect the genotoxicity of bactericide flutriafol.Results With and without S9 activation,there were negative results of the TA97,TA98,TA100 and TA102 strains in Ames test.The micronucleus rates in all doses were not significantly different from that of the control group.For the tail DNA% of comet assay there was a significant difference between the negative control and the treated group(P0.05) in dose of 80 mg/(kg·bw),while there was no significant difference between the negative control and the treated groups(P0.05) in other dose.The results of genetic toxicity tests were all negative.Conclusion The bactericide flutriafol had no genetic toxicity in this test.

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Available abstract

Objective To study the genotoxicity of bactericide flutriafol.Methods The Ames test,micronucleus test and comet assay were used to detect the genotoxicity of bactericide flutriafol.Results With and without S9 activation,there were negative results of the TA97,TA98,TA100 and TA102 strains in Ames test.The micronucleus rates in all doses were not significantly different from that of the control group.For the tail DNA% of comet assay there was a significant difference between the negative control and the treated group(P0.05) in dose of 80 mg/(kg·bw),while there was no significant difference between the negative control and the treated groups(P0.05) in other dose.The results of genetic toxicity tests were all negative.Conclusion The bactericide flutriafol had no genetic toxicity in this test.

Key concepts: Genotoxicity, Ames test, Comet assay, Micronucleus test, Micronucleus, Toxicology, Significant difference, Positive control

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