2013•Journal of Binzhou Medical UniversityRequires access
The relationship between expression of MAGE-3 and metastasis,prognosis in patients with non-small cell lung cancer
Meihua Gao
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Abstract
Objective To study the relationship between expression of melanoma antigen-3(MAGE-3) and metastasis,prognosis in patients with lung cancer.Methods The expression of MAGE-3 in 74 non-small cell lung cancer(NSCLC) tissues and 15 adjacent non-cancerous lung tissues was detected by immunohistochemistry LSAB method.Results The expression of MAGE-3 in lung cancer tissues was significantly higher than that in adjacent non-cancerous lung tissues(P0.05).The expression of MAGE-3 in adenocarcinoma was significanty higher than of that in squamous cell carcinomas(P005).The metastasis,prognosis rates(DFS) in patients with lung cancer and MAGE-3 expression was higher than that in not MAGE-3 expression group(P0.05).The difference of metastasis,prognosis rates in adenocarcinoma group with different expression of MAGE-3 was significantly.Conclusion Detection of the MAGE-3 expression in lung cancer was helpful in predicting prognosis of lung cancer and guiding the multimodality therapy for lung cancer.