Expression and Correlation of Vascular Endothelial Growth Factor and Angiopoietin-2 in Patients with Uterus Myoma

【Objective】To investigate the expression of angiopoietin-2(Ang-2) and vascular endothelial growth factor(VEGF) in uterus myoma,and the correlation between them,and their role in the pathogenesis and development of uterus myoma.【Methods】 The expression of VEGF and Ang-2 of 50 uterus myoma tissues and peri-myoma normal tissues were detected by immune histochemistry S-P method.And also their expression intension was tested by image analysis method.【Results】The positive rate of Ang-2 and VEGF in 50 uterus myoma were 82% and 78%,respectively.Their expression in the groups of uterus myoma was higher than that of the controls(P0.01).Moreover,there was a close correlation between Ang-2 and VEGF expression levels(P0.01).【Conclusion】There are high expression of Ang-2 and VEGF in uterus myoma.VEGF and Ang-2 may involve in the pathogenesis of uterus myoma,and they are positively correlated.It presumes that VEGF and Ang-2 have synergistic effect in pathogenesis and development of uterus myoma.