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Effect of bcl-2 gene in promoting the growth of gastric carcinoma cells

Hong Lu

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Abstract

Objective To investigate the effect of bcl 2 gene in promoting the growth of gastric carcinoma cells.Methods The expressions of bcl 2 mRNA and bcl 2 protein in gastric carcinoma cells in 60 patients were detected by in situ hybridization and immunohistochemistry.Results In 60 cases of gastric carcinoma,the expression rates of bcl 2 protein and bcl 2 mRNA were 83.3%(50/60) and 90.0%(54/60) respectively.The expression level of bcl 2 mRNA was positively correlated with bcl 2 protein (r=0.999,P0.01).The expressions of bcl 2 protein and bcl 2 mRNA were both higher in well differentiated group than those in low differentiated group.Conclusion Over expression of bcl 2 may inhibit the apoptosis of gastric carcinoma cells and promote the growth of gastric carcinoma,as a result,may cause unlimited cell accumulation which might play an important role in the development and malignant course of gastric carcinoma.

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Objective To investigate the effect of bcl 2 gene in promoting the growth of gastric carcinoma cells.Methods The expressions of bcl 2 mRNA and bcl 2 protein in gastric carcinoma cells in 60 patients were detected by in situ hybridization and immunohistochemistry.Results In 60 cases of gastric carcinoma,the expression rates of bcl 2 protein and bcl 2 mRNA were 83.3%(50/60) and 90.0%(54/60) respectively.The expression level of bcl 2 mRNA was positively correlated with bcl 2 protein (r=0.999,P0.01).The expressions of bcl 2 protein and bcl 2 mRNA were both higher in well differentiated group than those in low differentiated group.Conclusion Over expression of bcl 2 may inhibit the apoptosis of gastric carcinoma cells and promote the growth of gastric carcinoma,as a result,may cause unlimited cell accumulation which might play an important role in the development and malignant course of gastric carcinoma.

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Available abstract

Objective To investigate the effect of bcl 2 gene in promoting the growth of gastric carcinoma cells.Methods The expressions of bcl 2 mRNA and bcl 2 protein in gastric carcinoma cells in 60 patients were detected by in situ hybridization and immunohistochemistry.Results In 60 cases of gastric carcinoma,the expression rates of bcl 2 protein and bcl 2 mRNA were 83.3%(50/60) and 90.0%(54/60) respectively.The expression level of bcl 2 mRNA was positively correlated with bcl 2 protein (r=0.999,P0.01).The expressions of bcl 2 protein and bcl 2 mRNA were both higher in well differentiated group than those in low differentiated group.Conclusion Over expression of bcl 2 may inhibit the apoptosis of gastric carcinoma cells and promote the growth of gastric carcinoma,as a result,may cause unlimited cell accumulation which might play an important role in the development and malignant course of gastric carcinoma.

Key concepts: Gastric carcinoma, Messenger RNA, Immunohistochemistry, Apoptosis, Medicine, Gene, Carcinoma, In situ hybridization

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