2010•Unpublished venueRequires access

The expressions and their clinical significance of CD117 and CD34 in gastrointestinal stromal tumors(GISTs)

Wen Jian-cheng

Abstract

Objective:To study the expressions and their clinical significance of CD117 and CD34 in gastrointestinal stromal tumors (GISTs).Methods:Total of 46 cases of GISTs were studied by routine pathologic examination and immunohistochemical stains for CD117 and CD34.Results:All 46 cases of GISTs consisted of two basic cell types:spindle and epithelioid cells.The positive rates of CD117 and CD34 were 100% and 84.8% respectively in GISTs.52.2% cases of GISTs originated in stomach,26.1% cases in small intestine.Conclusion:Expressions of CD117 and CD34 are the special antibodies for GISTs,and the high positive expression of CD117 and CD34 plays a very important role in the diagnosis of GISTs.

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Key concepts: CD117, CD34, Stromal cell, Immunohistochemistry, GiST, Stomach, Pathology, Medicine