Helicobacter pylori infection and its possible role in coronary artery heart disease

Objective To study the relation Helicobacter pylori between(HP) infection and coronary artery heart disease (CHD) and its possible role in CHD and ACS. Methods Enzyme-linked immunosorbent assay was used to measure the plasma HP-IgM, IgG and radio-immunoassay was used to measure the plasma IL-6,ET in 73 patients with CHD(CHD group) and 26 patients without CHD(non-CHD group). The CHD group was divided into acute coronary syndrome group(group A,n=42) and stable symptom group(group B,n=31). Results ⑴The positive rate of HP-Ig-M, IgG was higher in CHD group (especially in group A) than that in non-CHD group (P0.05, P0.01 separately). ⑵The plasma levels of IL-6 were the same in group B and control group, but the plasma level was higher in group A than that in group B and control group (P0.01). The plasma level of ET in CHD group, especially in group A was higher than that in control group (P0.05,P0.01 separately). ⑶The positive rate of HP-IgM was too low to be statistical,but IgG was low correlated with ET (r=0.326,P0.05), was smartly correlated with IL-6(r=0.685,P0.05). Conclusion HP infection was related to CHD and ACS. HP infection may play an important role in the process of CHD, especially in ACS.