Research on the correlation of helicobacter pylori infection in patients with coronary heart disease

Objective To investigate the relationship of helicobacter pylori(Hp) infection and coronary heart disease(CHD),and to know more about the function of Hp infection in invasion of coronary heart disease.Methods The serum Hp-IgG antibodies were measured by ELISA in 144 patients with CHD(CHD group) and 96 healthy persons(non-CHD group).Cytotoxin associated protein A(CagA) antibodies were tested by western-blot assay in patients with Hp infection.Endothelin-1(ET-1) was tested by RIA.The differences between CHD patients with Hp infection and without Hp infection were compared.Results ①Prevalence of Hp-IgG was higher in CHD group(60.4%) than in non-CHD group(41.7%)(P 0.05).Removing common risk factors,Hp infection still could increase the danger of CHD(OR=2.09,95%CI 1.48-3.00).②Hp CagA+ could increase the danger of CHD,while CagA-didn't increase the danger of CHD obviously.③In CHD group,the level of ET-1 in patients with Hp infection was higher than that of patients without Hp infection(P 0.05).Conclusion Hp infection is a risk factor for CHD.CagA+ infection may increase the danger of CHD.The level of ET-1 in patients with Hp infection is improved obviously.