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[The effect of aldosterone of promotion on proliferation of ventricular fibroblasts].

Gong Sz, Liu Pq, Lu W, Tan Z, Fu Sg, Pan Jy

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Abstract

AIM: To study the effect of promoting aldosterone on proliferation of ventricular fibroblasts. METHODS: Assay of [3H]-TdR incorporation rate and RT-PCR were used. RESULTS: Aldosterone could promote [3H]-TdR incorporation of ventricular fibroblasts, the effective dose of aldosterone was among (1 x 10(-9)-1 x 10(-6))mol/L, and had dose-dependent manner, the c-fos gene was expressed after stimulated by aldosterone for 15 min, and studied the highest in 1 h, then reduced later. Spironolactone, aldosterone receptor antagonist could block the effect of aldosterone. CONCLUSION: Aldosterone promotes the proliferation of ventricular fibroblasts, mediated by aldosterone receptor.

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AIM: To study the effect of promoting aldosterone on proliferation of ventricular fibroblasts. METHODS: Assay of [3H]-TdR incorporation rate and RT-PCR were used. RESULTS: Aldosterone could promote [3H]-TdR incorporation of ventricular fibroblasts, the effective dose of aldosterone was among (1 x 10(-9)-1 x 10(-6))mol/L, and had dose-dependent manner, the c-fos gene was expressed after stimulated by aldosterone for 15 min, and studied the highest in 1 h, then reduced later. Spironolactone, aldosterone receptor antagonist could block the effect of aldosterone. CONCLUSION: Aldosterone promotes the proliferation of ventricular fibroblasts, mediated by aldosterone receptor.

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Available abstract

AIM: To study the effect of promoting aldosterone on proliferation of ventricular fibroblasts. METHODS: Assay of [3H]-TdR incorporation rate and RT-PCR were used. RESULTS: Aldosterone could promote [3H]-TdR incorporation of ventricular fibroblasts, the effective dose of aldosterone was among (1 x 10(-9)-1 x 10(-6))mol/L, and had dose-dependent manner, the c-fos gene was expressed after stimulated by aldosterone for 15 min, and studied the highest in 1 h, then reduced later. Spironolactone, aldosterone receptor antagonist could block the effect of aldosterone. CONCLUSION: Aldosterone promotes the proliferation of ventricular fibroblasts, mediated by aldosterone receptor.

Key concepts: Aldosterone, Spironolactone, Internal medicine, Endocrinology, Receptor, Mineralocorticoid receptor, Chemistry, Antagonist

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