Effects of combined use of sodium ferulate and astragalus injection(黄芪注射液) on changes ofhemor-rheology and renal function in patients with early diabetic nephropathy

Objective: To observe the influence of treatment with combiration of sodium ferulate and(astragalus) injection(黄芪注射液) on changes of hemorrheology and renal function in patients with early(diabetic) nephropathy(DN).Methods: One hundred and forty patients with early DN were(randomly) divided into two groups.The control group(n=70) was treated with conventional therapy for (diabetes) and diet(control) method,while the treatment group(n=70) was treated with sodium ferulate(combined) with(astragalus) injection additionally.The therapeutic course was 3 weeks.Results: In the(treatment) group,the hemorrheological parameters were(significantly) decreased(P0.05 or P0.01),the levels of urinary albumin excretion rate(UAER),the serum creatinine(SCr),blood urea nitrogen(BUN) and blood lipids were also significantly decreased compared to those before therapy(P0.05 or P0.01).The changes in the treatment group were superior to those of the control group.Conclusion: The treatment of sodium ferulate combined with astragalus injection for patiens with early DN can decrease the parameters of hemorrheology and blood lipids,improve(microcirculation),decrease UAER,ameliorate renal injury,and(improve) renal function.