Clinical Efficacy of Reduced Glutathione Combined with Astragalus Membranaceus Injection for Diabetic Nephropathy

OBJECTIVE:To observe the clinical efficacy of reduced glutathione(GSH)combined with Astragalus membranaceus injection for diabetic nephropathy(DN.) METHODS:50 cases of diabetes nephropathy were randomly divided into control group(n=25)and observation group(n=25.) Control group received Astragalus.membranaceus injection and observation group received GSH combined with Astragalus.membranaceus injection;The β2 microglobulin(β2MG),creatinine(Cr),urea nitrogen(BUN),urinary albumin excretion rate(UAER)and 24 hours urinary protein quantity(UPQ)were measured before and after treatment.RESULTS:Clinical index of 2 groups were improved significantly before and after treatment,there were statistical significance(P0.05);Clinical index of observation group were better than that of control group,there were statistical significance between control group and observation group(P0.05.)Apart from one case of hypoglycemia in patients,the remaining patients were no obvious adverse rections.CONCLUSION:GSH combined with Astragalus.membranaceus injection is safer,more effective and reliable than Astragalus.membranaceus injection alone in the treatment of DN.