Expression of p27 and Cyclin D_1 Proteins and Their Significance in Non-Hodgkin's Lymphoma

Objective To study expression of p27 and cyclin D 1 proteins and their significance in non-Hodgkin's lymphoma (NHL).Methods The expression of p27 and cyclin D 1 proteins were detected by imunohistochemical technique in 77 cases of NHL.Results Of 77 NHLs, the positive rates of p27 and cyclin D 1 protein were 51 9% (40/77) and 58 4% (45/77) respectively, and the positive intensity of p27 in low grade group was significantly higher than in high grade group (P0 01), whereas cyclin D 1 protein was reverse (P0 01), but their expression intensity was not related to immunological typing. There was significantly negative correlation between the expressions of p27 and cyclin D 1 protein (r=-0 7421).Conclusions The data suggest that p27 protein could effectively not inhibit the activity of cyclin D 1 protein. It may result in persistent proliferation and malignant transformation of lymphocytes due to the descent of p27 protein expression level.