2003•中国医师杂志Requires access

Expression of p27 and Cyclin D1 Proteins and Their Significance in Non-Hodgkin's Lymphoma

黎岳南, 蒋洁, 郑晖

Abstract

目的探讨p27和cyclin D1蛋白在非霍奇金淋巴瘤中的表达及其意义.方法利用免疫组织化学技术检测77例淋巴结非霍奇金淋巴瘤(NHL)中p27和cyclin D1 蛋白的表达.结果在NHL中p27和cyclin D1蛋白的阳性率分别为51.9%(40/77)和58.4%(45/77);低度恶性组的p27蛋白阳性表达强度明显高于高度恶性组(P＜0.01),而cyclin D1蛋白的阳性表达强度则明显低于高度恶性组(P＜0.01),但与免疫学分型均无关;NHL中p27和cyclin D1蛋白的阳性表达强度之间呈明显负相关(r=-0.7421).结论提示由于p27表达水平的下降,使其不能有效抑制cyclinD1蛋白的活性,从而使淋巴细胞高度增殖并发生恶性转化.

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Key concepts: Cyclin D1, Lymphoma, Cancer research, Hodgkin lymphoma, Biology, Expression (computer science), Genetics, Gene