2008•Journal of Apoplexy and Nervous DiseasesRequires access
Experimental study on the protein expression of NMDAR_2B and ERK1/2 in hippocampus of epilepsy rats induced by kainic acid
Weihong Lin
Open publisher page 0 citations
Abstract
Objective To observe the protein expression of NMDAR2B and ERK1/2 in hippocampus of epilepsy rats.Methods Epilepsy rat models were made by injecting kainic acid into amygdale under stereotactic instrument.70 male Wistar rats were divided randomly into 7 groups:(1)the control group;(2)the pseudo operation group;(3~7)epilepsy group,the protein expression of NMDAR2B and ERK1/2 in the rat brain was tested with the method of immunohistochemistry.Results In the 1,2 group,NMDAR2B and ERK1/2 positive cells distributed rarely in hippocampus.the protein expression of NMDAR2B increased until 24h after kindling and the protein expression of ERK1/2 increased 3h,then returned to normal level.Conclusion NMDAR2B and ERK1/2 are involved in the process of temporal epilepsy and the brain injury.