Influence of Ambroxol Hydrochloride and Clenbuterol Hydrochloride on Children's Cough Variant Asthma Symptoms Score and Lung Function

Objective To evaluate the influence of ambroxol hydrochloride and clenbuterol hydrochloride on children cough variant asthma symptoms score and lung function.Methods 90 children with cough variant asthma(CVA) were randomly divided into group A,B and C,with each group 30 cases.Group A was given montelukast-na,group B was given montelukast-na combined with ambroxol hydrochloride and clenbuterol hydrochloride,and group C was given ambroxol hydrochloride and clenbuterol hydrochlorid.The changes of asthma control test score(C-ACT) and pulmonary function(PEF mutation rate) were observed in the three groups after treatment.Results After two weeks' treatment,the asthma control test score in group B was significantly higher than that in group A and group C(P0.05),and the PEF mutation rate in group B was significantly lower than that in group A and group C(P0.05),but there's no significant difference between group A and group C in both the asthma control test score and the PEF mutation rate(P0.05).After four weeks' treatment,the asthma control test score and the PEF mutation rate in group A,group B and group C showed no statistically significant differences(P0.05).Conclusion Ambroxol hydrochloride and clenbuterol hydrochloride can significantly improve C-ACT score and lung function in children with CVA,and the combined use with montelukast-na has superimposition effect.