Administration of Flurbiprofen Axetil in Different Ways on Analgesia after Laparoscopic Cholecystectomy

Objective To explore the administration of flurbiprofen in different ways on analgesia after laparoscopic cholecystectomy(LC).Methods 60 elective LC patients with ASA I～II were randomly divided into A,B,C groups with 20 patients each.The three groups of patients maintained anesthesia with continuous intravenous infusion of remifentanil and propofol.Group A were intravenously infused flurbiprofen 1 mg/kg at the completion of surgery,Group B were intravenously infused flurbiprofen 1 mg/kg after intubation,Group C were intravenously infused fluoride axetil 1 mg/kg after intubation and the completion of surgery,to observe the three groups of patients 4,8,12,24 h pain visual analogue score(VAS),and record the anesthesia extubation,adverse events and postoperative analgesic use and so on. Results 4,8,12,24 h VAS in Group C were significantly lower than that in Group B(P0.05)and Group A(P0.01);Patient requirement of analgesic time in Group C was significantly longer than that in Group B(P0.05)and Group A(P0.01);Use of analgesic ratio in Group C was significantly less than that in Group B(P0.05)and Group A(P0.01);The three groups had no significant difference of adverse reaction rate.Conclusion The preoperative and intraoperative completion when the intravenous injection of flurbiprofen 1 mg/kg can produce better postoperative analgesia,decrease opioid drug dosis,without affecting the anesthesia recovery.