Detection and Clinical Analysis of Erythropoitin and Eeticulocyte in Patients with Advanced Cancer-Related Anemia

Objective To etect erythropoitin in patients with advanced cancer-related anemia and analyse the clinical signification.Methods Blood of patients with advanced cancer-related anemia were collected and erythropoitin was detected by radioimmuno-assay,hemoglobin(Hb) and reticulocyte(RET),reticulocyte production index(RPI) were detected also.Normal and patients with non-cancer-related anemia were employed as control groups.Results The erythropoitin of patients with advanced cancer-related anemia was(2.69±1.30) μg/L,hemoglobin(89.8±10.0) g/L,reticulocyte(2.78±1.06)%,RPI 1.44±0.32.Erythropoitin was(1.59±0.69) μg/L,hemoglobin(136.1±11.3) g/L,reticulocyte(1.17±0.35)%,RPI 0.98±0.25 in normal controls.Erythropoitin was(2.82±1.16) μg/L,hemoglobin(90.2±11.5) g/L,reticulocyte(5.7 ±2.7)%,RPI 2.34 ±0.35 in controls of non-cancer-related anemia.Compared with normal controls,the erythropoitin,hemoglobin and reticulocyte,RPI of patients with advanced cancer-related anemia were significant difference(P 0.01).The reticulocyte and RPI were significant different compared the patients with advanced cancer-related anemia with the patients with non-cancer-related anemia(P 0.01).The coefficient of correlation between erythropoitin and reticulocyte,RPI were significant different in the patients with advanced cancer-related anemia compared with the patients with non-cancer-related anemia(P 0.01).Conclusion The erythropoitin of patients with advanced cancer-related anemia increased responsively but the reactivity of erythropoitin decreased.