Therapeutic effect observations of pantoprazole for preventing and treating gastrointestinal reactions caused by chemotherapy drugs

Objective To explore the effect and safety of pantoprazole in preventing and inhibiting the gastrointestinal reactions caused by chemotherapy drugs.Methods A total of 90 advanced malignant tumor patients were selected and randomly divided into two groups.All patients received combined chemotherapy with adriamycin,platinum-based drugs,irinotecan and 5-fluorouracil.Meanwhile,the treatment group was administered with pantoprazole,dexamethasone and 5-HT3 inhibitor to prevent gastrointestinal reactions and protect gastric mucosa.The control group received dexamethasone and 5-HT3 inhibitor.The incidence rates of adverse gastrointestinal reactions within seven days,tolerance and safety of the patients after chemotherapy were observed and compared in the two groups.Results A total of 33 out of 44 patients in the treatment group had no gastrointestinal reactions within one week after chemotherapy with a control rate of 75%,while it was 52%(24/46) in the control group.11 out of 44 patients in the treatment group had partial gastrointestinal reactions one week after chemotherapy with a rate of 25%,which was 48%(22/46) in the control group.The differences between two groups had statistical significance(P0.05).Conclusion As a protective agent for gastric mucosa,pantoprazole combined with antiemetic drugs can obviously prevent and inhibit gastrointestinal reactions caused by chemotherapy drugs with a higher efficacy and safety and increased tolerance with no obvious side effects,which contribute to the patients′ compliance in the course of chemotherapy.