The clinical contrast study of determining glomerular filtration rate by calculation and using clearance rate of~(99m)Tc-DTPA

Objective To evaluate accuracy of determining glomerular filtration rate(GFR) by using the calculation method clinically.Methods GFRs from 60 patients in hospital suffering from different diseases were determined accurately using clearance rate of 99m Tc DTPA(Tc GFR),and the serum creatinine were determined and simultaneously GFRs calculated by WCP formula(WCP GFR) and creatinine clearance by Cockcroft/Gault formula(CG CCr).The correlation analysis was done between WCP GFR,CG GFR and Tc GFR in the group of renal failure and group of normal.The difference was compared between WCP GFR,CG GFR and Tc GFR and between the average odds of WCP GFR and Tc GFR and those of CG GFR and Tc GFR in two group.Results WCP GFR and CG CCr could reflect GFR accurately to some extent and WCP GFR amount was more proximate to Tc GFR and more accurate than other and could replace Tc GFR clinically.Conclusion WCP GFR is an accurate and simple method to determine GFR.