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2002•The Practical Journal of CancerRequires access

Expression Clinical Significance of CD44V6 and nm23-H1 Protein in Renal Cell Carcinoma

Hua Gu

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Abstract

Objective TO study the prognostic predictor for renal cell carinoma.Methods The expressions of CD44V6 mRNA and nm23 H1 mRNA in 60 cases of renal tumors were detected by in situ hybridization method.Results The positive rate of CD44V6 mRNA and nm23 H1 mRNA was 71.7% and 56.7% respectively.Histologic grading,clinical staging and metastasis potential of renal cell carcinoma were corralated with the high level expression of CD44V6 mRNA and the low level expression of nm23 H1 mRNA( P 0.05) .The expression of CD44V6 mRNA was negatively correlated with the expression of nm23 H1 mRNA( P 0.05, γ=-0.42).Conclusion The high level expression of CD44V6 mRNA and the low level expression of nm23 H1 mRNA might be some referenced indicator in evaluating differentiation of the tumor and in predicting lymph nodes metastasis.

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Objective TO study the prognostic predictor for renal cell carinoma.Methods The expressions of CD44V6 mRNA and nm23 H1 mRNA in 60 cases of renal tumors were detected by in situ hybridization method.Results The positive rate of CD44V6 mRNA and nm23 H1 mRNA was 71.7% and 56.7% respectively.Histologic grading,clinical staging and metastasis potential of renal cell carcinoma were corralated with the high level expression of CD44V6 mRNA and the low level expression of nm23 H1 mRNA( P 0.05) .The expression of CD44V6 mRNA was negatively correlated with the expression of nm23 H1 mRNA( P 0.05, γ=-0.42).Conclusion The high level expression of CD44V6 mRNA and the low level expression of nm23 H1 mRNA might be some referenced indicator in evaluating differentiation of the tumor and in predicting lymph nodes metastasis.

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Available abstract

Objective TO study the prognostic predictor for renal cell carinoma.Methods The expressions of CD44V6 mRNA and nm23 H1 mRNA in 60 cases of renal tumors were detected by in situ hybridization method.Results The positive rate of CD44V6 mRNA and nm23 H1 mRNA was 71.7% and 56.7% respectively.Histologic grading,clinical staging and metastasis potential of renal cell carcinoma were corralated with the high level expression of CD44V6 mRNA and the low level expression of nm23 H1 mRNA( P 0.05) .The expression of CD44V6 mRNA was negatively correlated with the expression of nm23 H1 mRNA( P 0.05, γ=-0.42).Conclusion The high level expression of CD44V6 mRNA and the low level expression of nm23 H1 mRNA might be some referenced indicator in evaluating differentiation of the tumor and in predicting lymph nodes metastasis.

Key concepts: Messenger RNA, Grading (engineering), Renal cell carcinoma, Metastasis, In situ hybridization, Clinical significance, Metastasis Suppressor Gene, Lymph

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Expression Clinical Significance of CD44V6 and nm23-H1 Protein in Renal Cell Carcinoma — Research Paper | ScholarLens