2000•PubMedRequires access
[The expression of CD15 mRNA CD44v6 mRNA and nm23H1 mRNA in breast cancer and their clinical significance].
Hua Gu, Ni Chen, R Zhan
Open publisher page 4 citations
Abstract
OBJECTIVE: To study the relationship of the expression of CD15 mRNA and its protein, CD44v6 mRNA and nm23H1 mRNA with the clinical pathology parameter and prognosis of breast cancer, and to investigate the correlation of the expression of CD15 mRNA with CD44v6 mRNA and nm23H1 mRNA. METHODS: Catalyzed signal amplification (CSA) method of in situ hybridization and immunohistochemistry were used to detect the expression of CD15 mRNA and its protein, CD44v6 mRNA and nm23H1 mRNA in 94 cases of breast cancer. RESULTS: The overexpression of CD15 mRNA and its protein and CD44v6 mRNA and the low expression nm23H1 mRNA were correlated with the grading, clinical stage, lymph node metastasis, recurrence and prognosis of breast cancer. Patients who had overexpression of CD15 mRNA and CD44v6 mRNA and low expression of nm23H1 mRNA had a higher lymph node metastatic rate and a lower survival rate. CONCLUSION: The expression of CD15 mRNA has a synergistic action in positive and negative regulation with that of CD44v6 mRNA and nm23H1 mRNA. Combining detection of the expression of these three mRNA is a reliable index to evaluate the metastasis, recurrence and prognosis of breast cancer.