Metoprolol Combined with Captopril Treating Chronic Heart Failure

Objective To study or evaluate the therapeutic effect and security of captopril combined with metoprolol treating chronic heart failure.MethodA total of 90 patients with coronary atherosclerotic heart disease accompanied with mild/midrange heart failure were chosen and divided into 3 groups randomly,including patients treated with metoprolol combinated with captopril(30 cases),patients treated with metoprolol only(30 cases),patients treated with captopril only(30 cases).Basing on the standard amount of drug consumption,the administration of metoprolol and captopril was begined with small dose and then increased to target dose.UCG was examined for 3 times within 8 months to evaluate left ventricular end diastolic volume.ResultsAfter the treatment,LVEF increased,LVESV and LVEDV decreased in three groups.Comparing with the group treated with metoprolol only and the group treated with captopril only,there were significant differences in the group treated with metoprolol combined with captopril(P0.05).24 case(80%) in the group treated with metoprolol combined with captopril reached tolerant target dose and its common side effect was dizziness.Comparing with other two groups,there were no obvious differences.No damage of livers and kidneys and no changes of hemogram,electrolyte or glycometabolism were found.ConclusionsBased on the standard amount of drug consumption,metoprolol combined with captopril is safe and effective to mild or midrange CHF and can improve the reshaping of left ventricle.