The effects of taking small doses of mifepristone before and after surgery for patients with uterine fibroids

Objective To explore The effects of the results of surgery for patients with uterine fibroids taking small doses of Mifepristone before and after surgery.Methods 180 cases of uterine fibroids patients were selected which come to our hospital from January 2011 to January 2013 for treatment.The patients were divided into treatment group,control group and blank group according to the stratified randomization method.There were 60 cases of patients in each group.The control group accepted the small doses of mifepristone for 100 days until surgery and the treatment group accepted small doses of mifepristone for 6months after surgery.The blank group accepted placebo from 100 days before until 6months after surgery.Then all of the patients accepted operation for treatment.ResultsThere was no statistically significant difference of the size of uterine fibroids,progesterone and estrogen level of the both groups at the first time for treatment(P0.05).The size of uterine fibroids and progesterone of treatment group and control group were significantly less than the blank group in the preoperative(P0.05).The blood loss during the operation,the numbers of days vaginal bleeding,operative time,the number of cases of postoperative fever,the days of the postoperative pain and the days of hospitalization of the treatment group and control group were all significantly lower than the blank group(P0.05).The levels of tumor tissue levels of progesterone receptor(PR)and epidermal growth factor receptor(EGFR)of the treatment group and control group were still lower than the blank group(P0.05).The menstruation returned days after the surgery of the treatment group were significantly higher than the control group and the blank group(P0.05);.The progesterone levels of the treatment group was significantly lower than the control group and blank group six months after of treatment(P0.05);The recurrence of the treatment group was significantly lower than the control group and blank group 6months and 12 months after operation(P0.05).Conclusion Preoperative low-dose mifepristone significantly inhibited tumor development,the size of uterine fibroids,reduce blood loss,and promote postoperative recovery,postoperative use of small doses of mifepristone can significantly reduce the recurrence rate in patients.