Long and Short Period Efficacy Observation of Different Doses of Mifepristone in the Treatment of Uterine Fibroids

OBJECTIVE:To investigate the long and short period efficacy and safety of different doses of mifepristone in the treatment of uterine fibroids.METHODS:120 cases of uterine fibroids were randomly divided into low-dose group and high-dose group with 60 cases in each group.Low-dose group was given 12.5 mg·d -1 mifepristone while high-dose group was given 25.0 mg·d -1 mife- pristone for 6 months.Therapeutic efficacies of 2 groups were observed after 3 months and 6 months,and clinical efficacy of different doses of mifepristone for uterine fibroids was compared.RESULTS:The effective rate of 6 months of treatment was significantly better than 3 months of treatment in 2 groups(P0.05);there were no significant differences between 2 groups at the same time (P0.05).The tumor volume after treatment of 2 groups was significantly smaller than before treatment(P0.05);but there were no significant differences between 2 groups at the same time(P0.05).Both groups had few minor liver dysfunctions,and returned to normal after stopping the drugs.CONCLUSION:The long course of mifepristone has good efficacy on uterine fibroids, which is not associated with drug dosage.