2005•Journal of Hangzhou Teachers CollegeRequires access

An experimental study of the increasing effects of Tetrandrine on apoptosis of hypertrophic scar-derived fibroblasts

Zhong Xiao-chun

Abstract

Objective: To investigate the effect of Tetrandrine on apoptosis of hypertrophic scar-derived fibroblasts.Methods: Hypertrophic scar-derived fibroblasts were harvested and cultured in vitro.Tetrandrine was added to the culture media in the experimental group.The rates of the cell apoptosis were compared between the experimental group and the control group after 24 hours of culture by the method of TUNEL.Results: Apoptosis of fibroblasts significantly increased after the use of Tetrandrine(P0.01).Conclusion: Tetrandrine could increase apoptosis of fibroblasts,and might prevent or treat scars.

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Key concepts: Tetrandrine, Apoptosis, Hypertrophic scar, TUNEL assay, In vitro, Fibroblast, Hypertrophic scars, Chemistry